Degree of joint risk factor control and incident chronic kidney disease among individuals with obesity
Authors' conclusion
The joint risk factor control is associated with an inverse association of CKD risk in an accumulative manner among individuals with obesity. Achieving ideal control over risk factors may effectively counterbalance the excessive risk of CKD typically associated with obesity.
Study context
- Population
- UK Biobank participants with obesity at baseline and matched normal weight controls; joint control of 6 chronic kidney disease (CKD) risk factors (blood pressure, HbA1c, LDL-C, albuminuria, smoking, physical activity)matched cohort
- Participants
- 97,538 vs 97,538
- Exposure
- Degree of joint risk factor control (six major CKD risk factors) among participants with obesity; normal weight controls as reference for excess risk
- Obesityn = 97,538
- Normal weightn = 97,538reference
- Outcome
- Incident CKD
Methodological detailsUK Biobank, matched normal weight controls, Cox proportional hazards models
- UK Biobank
- Matched normal weight controls
- Cox proportional hazards models
Main finding
As reported in the abstract
Incident CKD among participants with obesity
Hazard ratio (95% CI)
Each additional risk factor control11% reduced risk of CKD
0.89(0.86–0.91)
Optimal controlling of all six risk factors49% decrease in risk of CKD
0.51(0.43–0.61)
Each additional risk factor control, as printed
Observational data: associations, not effects.
Further findings
Effect modification of association between joint risk factor control and incident CKD
- More pronounced in men vs women
- P for interaction = 0.017
- More pronounced with lower vs higher healthy food score
- P for interaction = 0.033
- More pronounced in diabetes medication users vs non-users
- P for interaction = 0.014
Original publication
Degree of joint risk factor control and incident chronic kidney disease among individuals with obesity. Diabetes Obes Metab. Published 20 August 2024. doi:10.
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