Effects of Weight‐Loss Interventions on Kidney, Cardiometabolic and Anthropometric Outcomes in Adults With Chronic Kidney Disease (CKD) and Overweight or Obesity: A Systematic Review and Meta‐Analysis
Authors' conclusion
In CKD patients with overweight or obesity, all types of interventions (lifestyle, pharmacological, surgical) are effective for weight-loss. Incretin-based therapies confer additional nephroprotective effects by significantly reducing albuminuria.
Study context
- Population
- Overweight or obese adults with any stage of CKD; searches of PubMed, CENTRAL and Embase up to August 2025
- Participants
- 11,017 participants42 studies
- Comparison
- Weight-loss interventions vs control
- Outcome
- Kidney and cardiovascular outcomes and mortality
Methodological detailsupdated
- Updated
Pooled result
As reported in the abstract
Kidney, cardiovascular outcomes and mortality
Each group vs placeboMD, mL/min/1.73 m2 (95% CI)
Bariatric surgeryeGFR; I 2 = 1%
6.09(3.66–8.52)
- Pharmacological · I 2 = 86%
- reduction in urine albumin-to-creatinine ratio 41% (95% CI 29%–52%)
Further pooled results
| Outcome | MD (kg) (95% CI) | |
|---|---|---|
| Weight loss (anthropometric parameters)Lifestylevs PlaceboI 2 = 83% | −4.13 (−6.49 to −1.76) | |
| −10−505Difference, kg (linear scale) |
| Outcome | MD (mm Hg) (95% CI) | |
|---|---|---|
| SBPLifestylevs PlaceboI 2 = 45% | −3.10 (−7.59 to 1.38) | |
| −10−505Difference, mm Hg (linear scale) |
Weight loss (anthropometric parameters)
- Weight, BMI and waist circumference improved across all intervention categories
SBP
- Systolic and diastolic blood pressure (BP) showed modest, non-significant reductions following lifestyle interventions; data for pharmacological and surgical approaches were limited
Original publication
Effects of Weight‐Loss Interventions on Kidney, Cardiometabolic and Anthropometric Outcomes in Adults With CKD and Overweight or Obesity: A Systematic Review and Meta‐Analysis. Diabetes Obes Metab. Published 22 June 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →