Daily versus fortnightly oral vitamin D 3 in treatment of symptomatic vitamin D deficiency in children aged 1−10 years: An open labelled randomized controlled trial
Authors' conclusion
Daily and fortnightly oral vitamin D3 in similar cumulative doses are efficacious for treating symptomatic vitamin D deficiency in children (1-10 years). Treated children should be monitored for serum 25(OH)D, Ca and urinary calcium creatinine ratio.
Study context
- Population
- Children aged 1–10 years with symptomatic vitamin D deficiency74 evaluated at 12 weeks
- Participants
- 80 children
- Comparison
- Daily vs fortnightly oral vitamin D3
- Dn = 40
- Bn = 40
Methodological detailsopen-label
- Open-label
Primary result
As reported in the abstract
25(OH)D level in sufficiency range · 4 and 12 weeks
- All children in both arms achieved 25(OH)D in sufficiency range; no significant difference in geometric mean
- Significant increase in calcium (Ca) and P and fall in alkaline phosphatase (ALP) and parathyroid hormone (PTH) from baseline to 4 and 12 weeks in both regimens, no intergroup difference
Safety
Asymptomatic transient hypercalcemia · resolved spontaneously on follow-up
p −0.14
| Outcome | D | B |
|---|---|---|
| HypercalciuriaResolved spontaneously on follow-up | 5.7% | — not stated in the abstract |
— not stated in the abstract
Original publication
Daily versus fortnightly oral vitamin D 3 in treatment of symptomatic vitamin D deficiency in children aged 1−10 years: An open labelled randomized controlled trial. Clin Endocrinol (Oxf). Published 13 August 2024. doi:10.
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