Correlation Between Hemoglobin Glycation Index Measured by Continuous Glucose Monitoring With Complications in Type 1 Diabetes
Main finding · Microvascular complications by HGIResult — go to the resultOdds ratio 5.05 95% CI 1.02–24.8Authors' conclusion
High HGI measured by CGM may be a useful marker for increased risk of microvascular diabetic complications.
Study context
- Population
- Permanent continuous glucose monitoring (CGM) users with T1D or LADA; mean age 39.7 ± 14.7 years, 73.1% women, 15.5 years (IQR, 7.5–29) since diagnosis
- Participants
- 52 users
- Exposure
- High vs low CGM-derived hemoglobin glycation index
- Outcome
- Presence of microvascular complications by high vs low HGI
Main finding
Microvascular complications by HGI
Odds ratio
5.05
95% CI 1.02–24.8
P = 0.04
High HGIvs Low HGI
OR 5.05 (95% CI 1.02–24.8); P = 0.04
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | High HGI | Low HGI | P value |
|---|---|---|---|
| Measured HbA1cHigher with high HGI | 8.1 % [65 mmol/mol] | 6.9 % [52 mmol/mol] | P < 0.001 |
- Glucose management indicator (GMI) and mean glucose · GMI 7.0% vs 7.0%; similar
- P = 0.495
- GMI and mean glucose · mean glucose 153 mg/dL vs 153 mg/dL; similar
- P = 0.564
Prevalence of complications (all participants)
- DR
- 32.7%
- Chronic kidney disease (CKD)
- 25%
- Neuropathy
- 19.2%
Glycaemic measures (all participants)
- Median HbA1c
- 7.6% (60 mmol/mol)
- GMI
- 7.0% (53 mmol/mol)
- Average hemoglobin glycation index (HGI)
- 0.55% ± 0.66%
Time since diagnosis and CKD
- OR per time since diagnosis
- 1.09 (95% CI 1.02-1.16; P = .008)
Original publication
Correlation Between Hemoglobin Glycation Index Measured by Continuous Glucose Monitoring With Complications in Type 1 Diabetes. Endocr Pract. Published 7 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →