Thioredoxin-Interacting Protein (TXNIP) DNA methylation is associated with glycemic control over 28 years in type 1 diabetes: findings from the Pittsburgh Epidemiology of Diabetes Complications (EDC) study
Authors' conclusion
Our results extend prior findings that TXNIP hypomethylation relates to worse glycemic control in type 1 diabetes by demonstrating the association persists over the long term. Additionally, the associations with triglycerides, pulse rate, and ACR suggest TXNIP DNAme could play a role in vascular damage independent of HbA1c. These findings strengthen potential for interventions targeting TXNIP to improve glycemic control in type 1 diabetes through its role in SLC2A1/glucose transporter 1-mediated glucose regulation.
Study context
- Population
- Childhood onset (<17 years) T1D, Pittsburgh Epidemiology of Diabetes Complications study
- Participants
- 411 participants
- Outcome
- Association of whole blood DNA methylation with concurrent and future HbA1c
- Follow-up
- 28 years
Methodological detailslongitudinal, Mendelian randomization
- Longitudinal
- Mendelian randomization
Main finding
As reported in the abstract
- DNA methylation at cg19693031 (TXNIP) and cg21534330 (Casein Kinase 1 Isoform Delta) significantly inversely associated with concurrent hemoglobin A1c (HbA1c)
- Hypomethylation of cg19693031 associated with consistently higher HbA1c over 28 years
Observational data: associations, not effects.
Further findings
Other clinical risk factors · 28 years
- Hypomethylation of cg19693031 associated with higher TG, pulse rate and albumin:creatinine ratio independently of HbA1c
meQTLs
- meQTLs in SLC2A1/SLC2A1-AS1 significantly associated with cg19693031 DNA methylation
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Original publication
TXNIP DNA methylation is associated with glycemic control over 28 years in type 1 diabetes: findings from the Pittsburgh Epidemiology of Diabetes Complications (EDC) study. BMJ Open Diabetes Res Care. Published 5 January 2023. doi:10.
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