Increased Glycation Ratio and Risk of Complications in Latent Autoimmune Diabetes in Adults Compared With Type 1 Diabetes Onset before 30 Years: A Cohort Study
Authors' conclusion
LADA cohort showed a higher glycation rate and lower time in hypoglycemia and variability. Microvascular complications were more common in T1D, but after adjusting for diabetes duration, macrovascular and microvascular risks were greater in LADA.
Study context
- Population
- Adults with T1D onset <30 years or Latent Autoimmune Diabetes in Adults (LADA) diagnosed ≥30 years with ≥80% continuous glucose monitoring (CGM) coverage 56 days prior to HbA1c
- Participants
- 890 vs 555
- Exposure
- LADA vs T1D
- LADAn = 890
- T1Dn = 555reference
- Outcome
- Estimated risk of macrovascular complications
Methodological detailsmulticenter, observational, Logistic regression to model risk of complications
- Multicenter
- Observational
- Logistic regression to model risk of complications
Main finding
As reported in the abstract
Observational data: associations, not effects.
Further findings
Personal glycation ratio · higher in LADA · adjusted for diabetes duration and BMI
P < 0.001
TBR70 · higher in T1D · adjusted for diabetes duration
P < 0.001
TBR54 · higher in T1D · adjusted for diabetes duration
P < 0.001
CV · higher in T1D · adjusted for diabetes duration
P < 0.001
Within-day CV · higher in T1D · adjusted for diabetes duration
P < 0.001
HbA1c
P = 0.017
Microvascular complications (unadjusted)
P < 0.001
Daily total insulin
P = 0.006
Daily basal insulin
P = 0.002
| Outcome | T1D | LADA |
|---|---|---|
| Estimated risk of microvascular complicationsAdjusted for diabetes duration | 29.1% (95% CI 25.1–33.5) | 46.1% (95% CI 40.4–52.0) |
Original publication
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