Cord Blood Plasma Metabolome-wide Associations With Height From Birth to Adolescence
Authors' conclusion
In this prospective study of US understudied urban, low-income, racially diverse children, we demonstrated that cord plasma metabolites were significantly associated with postnatal attained height at different age windows as well as height trajectories from birth to adolescence. We also revealed how these associations differed by children's sex and OWO status.
Study context
- Population
- US understudied urban, low-income, racially diverse children, Boston Birth Cohort; cord plasma metabolites and height from birth to adolescence
- Outcome
- Attained height and longitudinal height trajectories
- Follow-up
- Birth to adolescence
Methodological detailsmetabolome-wide association study, functional principal component analysis
- Metabolome-wide association study
- Functional principal component analysis
Main finding
As reported in the abstract
Cord metabolites correlated with FPC1 (overall height by age) after multiple testing
1
Metabolites with significant overall effect on FPC2 (speed of pubertal height growth), females
27
Metabolites with significant overall effect on FPC2 (speed of pubertal height growth), males
18
Observational data: associations, not effects.
Further findings
Associations by OWO status
- Associations with height differed between OWO and non-OWO children, especially among females
Original publication
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