The bi-directional association between bipolar disorder and obesity: Evidence from Meta and bioinformatics analysis
Authors' conclusion
Our study shows unequivocal evidence of a bi-directional association between bipolar disorder and obesity, but more crucially, it provides a snapshot of the molecular signature of obesity in bipolar patients as a result of psychotropic medication.
Study context
- Population
- Studies of obesity and bipolar disorder; databases searched through June 25, 202018 studies
- Comparison
- Obesity vs bipolar disorder
- Outcome
- Bidirectional association between obesity and bipolar disorder
Methodological detailsNewcastle-Ottawa Scale quality rating, Gene Expression Omnibus data sets (GSE5392, GSE87610, GSE35977)
- Newcastle-Ottawa Scale quality rating
- Gene Expression Omnibus data sets (GSE5392, GSE87610, GSE35977)
Pooled result
As reported in the abstract
Obesity → risk of developing bipolar disorder, pooled aOR
1.32
95% CI 1.01–1.62
Bipolar disorder → chance of obesity, pooled aOR
1.68
95% CI 1.35–2
Further pooled results
Molecular signature of obesity in bipolar disorder after psychotropic treatment (bioinformatics)
- UBAP2L AUC (p = 1.1e-04)
- 0.806
- NOVA2 AUC (p = 6.7e-03)
- 0.73
- Genes activated after psychotropic treatment include CYBB, C3, OLR1, CX3CR1, C3AR1, CD53, AIF1, LY86, BDNF, ALOX5AP, CXCL10; mostly mesodermal and PI3K-Akt signaling pathway
Original publication
The bi-directional association between bipolar disorder and obesity: Evidence from Meta and bioinformatics analysis. Int J Obes (Lond). Published 18 February 2023. doi:10.
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