Adipose tissue function and insulin sensitivity in syndromic obesity of Bardet-Biedl syndrome
Authors' conclusion
Although childhood-onset extreme obesity is a feature of BBS, detailed studies of insulin sensitivity and adipose tissue structure and function are similar to common polygenic obesity. This study adds to the literature by suggesting that it is the quality and quantity of adiposity not the duration that drives the metabolic phenotype.
Study context
- Population
- Adults with bardet-Biedl syndrome (BBS) and BMI-matched polygenic obese controls, national centre for BBS, Birmingham, UK
- Participants
- 9 vs 10
- Exposure
- BBS vs BMI-matched polygenic obese controls
- BBSn = 9
- Controlsn = 10reference
- Outcome
- Differences in insulin resistance, metabolic profile, adipose tissue function and gene expression
Methodological detailsprospective
- Prospective
Main finding
As reported in the abstract
Insulin sensitivity and adipose tissue structure, function and gene expression
- Adipose tissue structure, gene expression and in vivo functional analysis similar between BBS and polygenic obesity
- No significant differences in insulin sensitivity (hyperinsulinemic-euglycemic clamp and surrogate markers) between BBS and obese controls
- No significant changes in adipokines, cytokines, pro-inflammatory markers and adipose tissue RNA transcriptomic
Observational data: associations, not effects.
Original publication
Adipose tissue function and insulin sensitivity in syndromic obesity of Bardet-Biedl syndrome. Int J Obes (Lond). Published 20 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →