Gestational diabetes & diabetes in pregnancy
Continuous Glucose Monitoring Metrics in High-Risk Pregnant Women with Type 2 Diabetes
Authors' conclusion
In this high-risk group of women with T2DM, CGM metrics only improved during pregnancy in those with greater sensor use and were associated with LGA in early pregnancy and neonatal hypoglycemia throughout.
Study context
- Population
- High-risk pregnant women with T2D using Freestyle Libre continuous glucose monitoring (CGM); mean age 33 years, 73% Aboriginal or Torres Strait Islander, 32% living remotely41 used CGM
- Participants
- 57 women
- Outcome
- CGM metrics, early to late pregnancy, and associations with neonatal outcomes
- Follow-up
- Mean 16 and 35 weeks
Methodological detailsLogistic regression of CGM metrics vs neonatal hypoglycaemia (glucose <2.6 mmol/L requiring intravenous dextrose) and large for gestational age (LGA) (>90th percentile for gestational age and sex), Pregnancy-specific target range 3.5-7.8 mmol/L (63-140 mg/dL)
- Logistic regression of CGM metrics vs neonatal hypoglycaemia (glucose <2.6 mmol/L requiring intravenous dextrose) and LGA (>90th percentile for gestational age and sex)
- Pregnancy-specific target range 3.5-7.8 mmol/L (63-140 mg/dL)
Main finding
As reported in the abstract
- Sensor use >50% (n = 29): change in mean time in range (TIR)
- increased by 9%
- Sensor use >50%: change in TAR
- reduced by 12%
- Sensor use >50%: change in average glucose
- reduced by 1 mmol/L
- Sensor use >50%: change in TBR
- increased by 3%
- Reduction in risk of neonatal complications per 1% increase in TIR
- 4%-5%
Observational data: associations, not effects.
Original publication
Continuous Glucose Monitoring Metrics in High-Risk Pregnant Women with Type 2 Diabetes. Diabetes Technol Ther. Published 30 October 2023. doi:10.
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