Gestational diabetes & diabetes in pregnancy
C-reactive protein during pregnancy and in the early postpartum predicts adverse metabolic health outcomes at 1 year postpartum in women with gestational diabetes
Authors' conclusion
CRP during pregnancy and in the early postpartum predicted an adverse cardio-metabolic profile in women with prior GDM at 1 year postpartum independent of weight.
Study context
- Population
- Women with gestational diabetes mellitus (GDM) at 28–32 weeks gestational age (GA), followed to 1 year postpartum
- Participants
- 211 women
- Primary endpoint
- Adverse metabolic outcomes (weight, total and central body fat, insulin resistance and secretion indices, MetS) by perinatal CRP
- Follow-up
- 1 year postpartum
Methodological detailsprospective
- Prospective
Primary result
As reported in the abstract
- C-reactive protein (CRP) predicted increased weight, body fat and visceral adipose tissue (VAT), insulin resistance (higher HOMA-IR, lower MATSUDA), absolute insulin secretion (HOMA-B, AUCins/glu), reduced adjusted insulin secretion (ISSI-2) and higher metabolic syndrome (MetS) prevalence
- all p ≤ 0.036
- Independent of weight (VAT, insulin resistance and secretion indices, MetS)
- all p ≤ 0.032
- Independent of body fat (VAT, MATSUDA, MetS)
- all p ≤ 0.038
Original publication
C-reactive protein during pregnancy and in the early postpartum predicts adverse metabolic health outcomes at 1 year postpartum in women with gestational diabetes. Cardiovasc Diabetol. Published 27 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →