Gestational diabetes & diabetes in pregnancy
The Prognosis of Glutamic Acid Decarboxylase Antibodies in Women With Hyperglycemia in Pregnancy
Main finding · Cesarean deliveryResult — go to the resultAdjusted odds ratio 0.49 95% CI 0.26–0.92Authors' conclusion
Universal measurement of GADA in women with HIP highlighted that 7.4% had positive GADA. No association was observed between GADA and HIP-related adverse pregnancy outcomes, except a lower risk of cesarean delivery.
Study context
- Population
- Consecutive women with hyperglycemia in pregnancy (HIP) measured for glutamic acid decarboxylase antibodies (GADA) at HIP care initiation, 2012–2017, university hospital near Paris, France
- Participants
- 1,182 women
- Exposure
- Positive vs negative GADA
- Positive GADAn = 87
- Outcome
- HIP-related adverse pregnancy outcomes: gestational weight gain, insulin therapy, cesarean delivery, hypertensive disorders, small-for-gestational-age infant, prematurity, neonatal hypoglycemia
Methodological detailssingle-centre, post hoc analyses
- Single-centre
- Post hoc analyses
Main finding
Cesarean delivery
Adjusted odds ratio
0.49
95% CI 0.26–0.92
P = 0.026
By group
Positive GADAvs Negative GADA
aOR 0.49 (95% CI 0.26–0.92); P = 0.026
As reported in the abstract
Observational data: associations, not effects.
Further findings
FPG during early HIP screening · higher with positive GADA
P < 0.001
Fructosamine · HIP care initiation · higher with positive GADA
P < 0.05
- Prevalence of positive GADA
- 7.4% · 87
Homeostatic model assessment, insulin resistance (HOMA-IR) and HOMA-B
- HOMA-IR and HOMA-B similar in both groups
Original publication
The Prognosis of Glutamic Acid Decarboxylase Antibodies in Women With Hyperglycemia in Pregnancy. J Clin Endocrinol Metab. Published 27 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →