Continuous glucose monitoring‑derived time in range and coefficient of variation (CV) are associated with elevated risk of adverse kidney outcomes for patients with type 2 diabetes
Authors' conclusion
This study found that TIR and CV are significantly associated with CKD progression, proteinuria deterioration, all-cause mortality, and the risk of MACE.
Study context
- Population
- Patients with T2D hospitalized July 2020 to December 2022; Continuous glucose monitoring (CGM) at baseline (3-day glucose profiles)
- Participants
- 1,274 patients
- Exposure
- CGM-derived time in range (TIR) and CV and chronic-kidney-disease (CKD) progression
- Outcome
- CKD progression
- Follow-up
- Median 923 days
Main finding
As reported in the abstract
TIR, HR per 10% increment (95% CI 0.83-0.91); lower TIR categories had markedly increased risk
0.90
CV, HR per 10% increment (95% CI 1.07-1.59); higher CV positively related to risk
1.30
Observational data: associations, not effects.
Secondary outcomes
Albuminuria worsening, all-cause mortality, MACE
- TIR and CV significantly associated with proteinuria deterioration, all-cause mortality and MACE risk
Subgroups and sensitivity analyses
- Results consistent across subgroups and sensitivity analyses
Original publication
Continuous glucose monitoring‑derived time in range and CV are associated with elevated risk of adverse kidney outcomes for patients with type 2 diabetes. Diabetes Metab. Published 9 February 2025. doi:10.
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