Comprehensive Multiple Risk Factor Control in Type 2 Diabetes to Mitigate Heart Failure Risk: Insights From a Prospective Cohort Study
Main finding · HF risk by degree of risk factor control in T2DResult — go to the resultHazard ratio 0.33 95% CI 0.20–0.54Authors' conclusion
Comprehensive management of risk factors is inversely associated with HF risk, and optimal risk factor control may prolong HF-free survival time among individuals with T2D.
Study context
- Population
- Individuals with T2D and matched non-T2D controls, UK Biobank cohortmatched cohort
- Participants
- 11,949 vs 47,796
- Exposure
- Degree of comprehensive risk factor control in T2D; T2D vs matched non-T2D controls
- T2Dn = 11,949
- Non-T2D controlsn = 47,796reference
- Outcome
- HF risk and HF-free survival time
- Follow-up
- Median 12.3 years
Methodological detailsmatched non-T2D controls, UK Biobank
- Matched non-T2D controls
- UK Biobank
Main finding
HF risk by degree of risk factor control in T2D
Hazard ratio
0.33
95% CI 0.20–0.54
Optimal control of ≥6 risk factors
HR 0.33 (95% CI 0.20–0.54)
As reported in the abstract
- Each additional risk factor controlled: average lower risk of heart failure (HF)
- 19%
Observational data: associations, not effects.
Further findings
Incident HF · median follow-up 12.3 years
| Outcome | HR (95% CI) | |
|---|---|---|
| HF risk in T2D with high degree of risk factor controlvs non-T2D controlsExcess HF risk attenuated to levels comparable to controls | 0.66 (0.40–1.07) | |
| 0.512Hazard ratio (log scale) |
HF risk in T2D with high degree of risk factor control vs non-T2D controls
- Longer HF-free survival time with high risk factor control
Original publication
Comprehensive Multiple Risk Factor Control in Type 2 Diabetes to Mitigate Heart Failure Risk: Insights From a Prospective Cohort Study. Diabetes Care. Published 13 August 2024. doi:10.
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