A Comprehensive Mendelian Randomization Study Investigating Multiple Exposures and Outcomes: Focusing on Nontoxic Goitre and Type 2 Diabetes Mellitus
Authors' conclusion
Our findings indicate a potential causal relationship between nontoxic goitre traits and T2DM. Specifically, our study addresses that NMG and T2DM may have a significant causal effect on each other in both directions.
Study context
- Population
- GWAS summary data: nontoxic goitre traits and T2D from FinnGen; fasting glucose, fasting insulin and HbA1c from the MRC Integrated Epidemiology Unit (IEU) open GWAS database
- Comparison
- Nontoxic goitre traits and T2D, in both directions
- Outcome
- T2D (goitre traits as exposure)
Methodological detailsmultiple exposures and outcomes, bidirectional (two stages), inverse-variance weighted, sensitivity analyses
- Multiple exposures and outcomes
- Bidirectional (two stages)
- Inverse-variance weighted
- Sensitivity analyses
Main finding
As reported in the abstract
Odds ratio (95% CI)P value
NDG
0.978(0.957–0.998)
P = 0.034NMG
0.941(0.902–0.982)
P = 0.008OUNGdecreased odds of T2D by 4.4%
0.966(0.938–0.995)
P = 0.023Further findings
Goitre traits (T2D as exposure; reverse direction)
| OR (95% CI) | P value | ||
|---|---|---|---|
| NDGT2D as exposure | 1.239 (1.020–1.504) | P = 0.031 | |
| NMGT2D as exposure | 0.669 (0.566–0.792) | P < 0.001 | |
| OUNGT2D as exposure | 0.694 (0.545–0.883) | P = 0.004 | |
| 0.512Odds ratio (log scale) |
Fasting glucose (NDG as exposure)
| OR (95% CI) | P value | ||
|---|---|---|---|
| NDG | 0.995 (0.990–0.999) | P = 0.011 | |
| 0.512Odds ratio (log scale) |
HbA1c (NMG as exposure)
| OR (95% CI) | P value | ||
|---|---|---|---|
| NMG | 0.992 (0.986–0.998) | P = 0.015 | |
| 0.512Odds ratio (log scale) |
Glycemic traits and nontoxic goitre traits
- No evidence of a positive association between glycemic traits and nontoxic goitre traits
- P > 0.05
Original publication
A Comprehensive Mendelian Randomization Study Investigating Multiple Exposures and Outcomes: Focusing on Nontoxic Goitre and Type 2 Diabetes Mellitus. Clin Endocrinol (Oxf). Published 11 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →