Comprehensive analyses of circulating cardiometabolic proteins and objective measures of fat mass
Authors' conclusion
This is the first large study showing associations between fat mass and circulating cardiometabolic proteins. Proteins not previously linked to body size are implicated in modulation of postsynaptic signals, inflammation, and carcinogenesis.
Study context
- Population
- Swedish women aged 55–85 years; fat mass measured by DXA; 276 proteins assessed with three Olink Proseek Multiplex panels
- Participants
- 4,950 Swedish women
- Outcome
- Associations of total fat mass index (FMI) with circulating cardiometabolic proteins
Methodological detailsdiscovery and replication samples, random forest, multivariable linear regression, principal component analysis
- Discovery and replication samples
- Random forest
- Multivariable linear regression
- Principal component analysis
Main finding
As reported in the abstract
- Proteins associated with total fat mass index (FMI) after adjustment for multiple testing in discovery and replication multivariable analyses
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Observational data: associations, not effects.
Further findings
- Similar patterns observed for regional fat mass measures
Original publication
Comprehensive analyses of circulating cardiometabolic proteins and objective measures of fat mass. Int J Obes (Lond). Published 7 August 2023. doi:10.
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