Comparison of various treatment modalities for the management of bone marrow edema syndrome/transient osteoporosis in men and non-pregnant women: a systematic review
Authors' conclusion
BMES/TO has been treated with many non-standardized measures due to the low number of highly reliable studies. Current literature shows promising results with regard to the reduction of the clinical course of BMES/TO, but further large multicenter randomized controlled trials, as well as standardized radiological and clinical scores, are warranted to acquire evidence-based recommendations on the therapeutic algorithm.
Study context
- Population
- Men and non-pregnant women with bone marrow edema syndrome/transient osteoporosis (bone marrow edema syndrome (BMES)/transient osteoporosis (TO))36 articles
- Participants
- 880 men
- Comparison
- Various treatment modalities for BMES/TO
- Outcome
- Pain resolution
Methodological detailsQuality assessed with modified Delphi technique, Methodological Index for Non-Randomized Studies (MINORS) criteria and Cochrane risk of bias tool
- Quality assessed with modified Delphi technique, MINORS criteria and Cochrane risk of bias tool
Pooled result
As reported in the abstract
- <1 month: bisphosphonates more efficient than CD
- 1-3 months: iloprost more efficient than bisphosphonates and CD
- 3-6 months: bisphosphonates, iloprost and CD equal
- 6-12 months: CD and extracorporeal shockwave therapy (ESWT) excellent results, followed by bisphosphonates and conservative group (CG)
Further pooled results
Bone marrow edema (BME) resolution on magnetic resonance imaging (MRI)
- 1-3 months: bisphosphonates, iloprost and CD relatively the same; CG least promising
- 3-6 months: CD best, followed by ESWT, CG and bisphosphonates
- 6-12 months: ESWT best vs conservative, bisphosphonates and iloprost
Original publication
Comparison of various treatment modalities for the management of bone marrow edema syndrome/transient osteoporosis in men and non-pregnant women: a systematic review. Osteoporos Int. Published 12 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →