Comparison of pharmacodynamics and pharmacokinetics of ultra‐rapid‐acting insulin aspart and rapid‐acting insulin aspart around continuous moderate intensity exercise in adults with type 1 diabetes: A randomised controlled trial
Authors' conclusion
Insulin dose reductions around acute moderate-intensity exercise yield similar glucose-lowering effects with URA-IAsp and IAsp. The extent of dose reductions exerts greater influence on glycaemia than the type of fast-acting insulin.
Study context
- Population
- Adults with T1D; insulin with standardised breakfast 60 min before 45 min cycling at ≈61% V̇O2peak, same dose 4 h later with identical lunchcompleted 4 visits
- Participants
- 43 adults
- Comparison
- Ultra-rapid-acting insulin aspart (URA-IAsp) vs insulin aspart (IAsp) at 50% or 75% reduced dose around moderate-intensity exercise
- Primary endpoint
- Four-way comparison of blood glucose change from exercise start to end
- Follow-up
- Exercise start to end
Methodological detailsdouble-blind, laboratory-controlled, crossover
- Double-blind
- Laboratory-controlled
- Crossover
Primary result
As reported in the abstract
Blood glucose change during exercise
50% URA-IAsp
−4.0
± 2.8 · mmol L-1
50% IAsp
−5.1
± 3.0 · mmol L-1
75% URA-IAsp
−2.8
± 3.3 · mmol L-1
75% IAsp
−3.4
± 3.3 · mmol L-1
50% URA-IAsp vs all other conditions: all p > 0.05 · 50% IAsp vs 75% URA-IAsp and 75% IAsp: both p < 0.05
Further findings
Blood insulin concentrations · from 30 min after first injection
- Differences between trials resulted only from insulin dose, not insulin type
Original publication
Comparison of pharmacodynamics and pharmacokinetics of ultra‐rapid‐acting insulin aspart and rapid‐acting insulin aspart around continuous moderate intensity exercise in adults with type 1 diabetes: A randomised controlled trial. Diabetes Obes Metab. Published 10 February 2026. doi:10.
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