Comparison of Diluted Insulin (U10) Versus Standard (U100) Insulin in Automated Insulin Delivery Systems: Reducing Time Below Range in Young Children
Authors' conclusion
The use of diluted insulin in young CwT1D, who require low insulin doses and use an automated insulin delivery system, reduces time below range with no evidence of increased hyperglycaemia.
Study context
- Population
- Children aged 0–4 years with T1D using AID systems, 2020–2025, diabetes registrymatched controls
- Participants
- 19 vs 27
- Exposure
- Diluted insulin vs standard insulin in AID systems
- Diluted insulinn = 19
- Controlsn = 27reference
- Outcome
- Change in TBR <3.9 mmol/L from 3 months (HbA1c-adjusted mixed-effects model)
- Follow-up
- 9 and 12 months
Methodological detailsregistry-based, age and gender-matched control group, HbA1c-adjusted mixed-effects model
- Registry-based
- Age and gender-matched control group
- HbA1c-adjusted mixed-effects model
Main finding
As reported in the abstract
- Compared with controls, children using diluted insulin had lower TBR <3.9 mmol/L at later follow-up visits
- HbA1c-adjusted mixed-effects model
Observational data: associations, not effects.
Further findings
| Outcome | Diluted insulin | P value |
|---|---|---|
| TBR <3.9 within diluted insulin users, before vs after 3 monthsFrom 4.6% ± 4.1% to 2.7% ± 2.5% | 2.7% ± 2.5% | P = 0.008 |
| TBR <3.0 within diluted insulin users, before vs after 3 monthsFrom 1.2% ± 1.8% to 0.4% ± 0.6% | 0.4% ± 0.6% | P = 0.01 |
- TBR <3.9 within diluted insulin users, before vs after 3 months: remained low through 12 months
- TBR <3.0 within diluted insulin users, before vs after 3 months: remained low through 12 months
Other CGM measures · over time
- No significant between-group changes in other CGM measures over time
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Comparison of Diluted Insulin (U10) Versus Standard (U100) Insulin in Automated Insulin Delivery Systems: Reducing Time Below Range in Young Children. Diabetes Obes Metab. Published 13 July 2026. doi:10.
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