Comparative study on the predictive value of TG/HDL-C, triglyceride glucose (TyG) and TyG-body mass index (TyG-BMI) indices for 5-year mortality in critically ill patients with chronic heart failure: a retrospective study
Authors' conclusion
As continuous variables, all three indices were significantly associated with 5-year mortality risk in critically ill patients with CHF. Although these IR indices did not improve the predictive power of the basic model in patients with CHF, the TyG index appears to be the most promising index (vs. TyG-BMI and TG/HDL-C ratio) for prevention and risk stratification in critically ill patients with CHF.
Study context
- Population
- Critically ill patients with chronic HF from the Multiparameter Intelligent Monitoring in Intensive Care (MIMIC) III and IV databases
- Participants
- 1,329 patients
- Exposure
- TyG index vs TyG-BMI vs TG/HDL-C as predictors of 5-year mortality
- Outcome
- 5-year mortality
- Follow-up
- 5 years
Methodological detailsMIMIC III and IV databases
- MIMIC III and IV databases
Main finding
As reported in the abstract
| Group | HR | AUC |
|---|---|---|
| TyG | 1.56 (95% CI 1.29-1.9) | 0.608 [0.571-0.645] |
| TyG-BMI | 1.002 (95% CI 1.000-1.003) | 0.558 [0.522-0.594] |
| TG/HDL-C | 1.01 (95% CI 1.00-1.03) | 0.561 [0.524-0.598] |
HR
TyG1.56 (95% CI 1.29-1.9)
TyG-BMI1.002 (95% CI 1.000-1.003)
TG/HDL-C1.01 (95% CI 1.00-1.03)
AUC
TyG0.608 [0.571-0.645]
TyG-BMI0.558 [0.522-0.594]
TG/HDL-C0.561 [0.524-0.598]
Observational data: associations, not effects.
Further findings
Adding TyG index to basic model for 5-year mortality
- AUC basic model
- 0.762
- AUC basic model + TyG index
- 0.769
- Difference not statistically significant
Subgroups: effect of TyG index on all-cause mortality
- Consistent across subgroups, no significant interaction
Original publication
Comparative study on the predictive value of TG/HDL-C, TyG and TyG-BMI indices for 5-year mortality in critically ill patients with chronic heart failure: a retrospective study. Cardiovasc Diabetol. Published 20 June 2024. doi:10.
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