Combined effect of adiposity and elevated inflammation on incident type 2 diabetes: a prospective cohort study
Authors' conclusion
Adiposity and elevated inflammation synergically lead to greater risks of incident diabetes than addition of each individual exposure. Strategies simultaneously targeting both risks should produce more benefits for diabetes prevention than through initiatives directed at each separate risk.
Study context
- Population
- Non-diabetic participants from a prospective cohort in China14,278 T2D occurred
- Participants
- 82,172 participants
- Exposure
- Adiposity and elevated inflammation, alone and jointly, vs neither
- Outcome
- Incident T2D
- Follow-up
- Median 11 years
Methodological detailsmultivariable-adjusted, time-to-event survival analyses on multiplicative and additive scales
- Multivariable-adjusted
- Time-to-event survival analyses on multiplicative and additive scales
Main finding
As reported in the abstract
Incident T2D, joint effect of overweight/obesity and elevated inflammation
Adjusted hazard ratio (CI)
Overweight/obesity
1.77(1.69–1.85)
Elevated inflammation
1.14(1.06–1.23)
Joint effect
2.08(1.97–2.19)
- Relative excess risk due to interaction
- 0.17 (0.05-0.28)
- Attributable proportion, overweight/obesity
- 71.30%
- Attributable proportion, elevated inflammation
- 12.96%
- Attributable proportion, interaction
- 15.74%
Observational data: associations, not effects.
Further findings
Incident diabetes, individual exposures (multivariable-adjusted)
- Elevated inflammation
- 1.12 (1.08-1.16)
- Overweight/obesity
- 1.76 (1.69-1.83)
- Central obesity
- 1.49 (1.44-1.55)
- Fatty liver
- 2.02 (1.95-2.09)
- Higher adiposity-associated risks and incidence rates of diabetes with elevated inflammation
Original publication
Combined effect of adiposity and elevated inflammation on incident type 2 diabetes: a prospective cohort study. Cardiovasc Diabetol. Published 20 December 2023. doi:10.
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