Cognitive Risk Stratification Score in Middle-aged and Older Adults With Type 2 Diabetes: A Cross-Sectional Study
Authors' conclusion
RSS in clinical practice, exemplified by the Integrated Metabolic Cognitive Risk Stratification Pathway, is a promising tool for rapid CI risk assessment in primary care. Its robust predictive accuracy and ease of use support its application for early intervention in middle-aged and older adults with T2DM. Future studies should validate its use longitudinally and across diverse populations to enhance generalizability.
Study context
- Population
- Adults aged 40–85 with T2D, primary care polyclinic in western Singapore, July 2023–February 2024
- Participants
- 150 adults
- Outcome
- Cognitive impairment status assessed by formal neuropsychological tests, including MoCA
Methodological detailsconvenience sampling, single primary care polyclinic
- Convenience sampling
- Single primary care polyclinic
Main finding
As reported in the abstract
Prediction of cognitive impairment
| Group | AUC | P | Optimal cutoff | Sensitivity | Specificity |
|---|---|---|---|---|---|
| Risk stratification score (RSS) | 0.802 | P < .001 | 0.3 | 63.5% | 86.8% |
Risk stratification score (RSS)
AUC0.802
PP < .001
Optimal cutoff0.3
Sensitivity63.5%
Specificity86.8%
Observational data: associations, not effects.
Further findings
Prevalence of cognitive impairment
- Cognitive impairment identified
- 49.3% (n = 74)
Original publication
Cognitive Risk Stratification Score in Middle-aged and Older Adults With Type 2 Diabetes: A Cross-Sectional Study. J Clin Endocrinol Metab. Published 4 February 2025. doi:10.
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