Frail hypertensive older adults with prediabetes and chronic kidney disease: insights on organ damage and cognitive performance - preliminary results from the CARYATID study
An erratum to this article was published (Cardiovasc Diabetol, 29 May 2024 ↗)
Authors' conclusion
Our study represents the pioneering effort to establish a significant correlation between albuminuria and eGFR with cognitive function in frail hypertensive older adults afflicted with prediabetes and CKD.
Study context
- Population
- Consecutive frail hypertensive older adults (>65 years) with prediabetes, Montreal Cognitive Assessment (MoCA) score <26 and chronic kidney disease (CKD) with estimated glomerular filtration rate (eGFR) >15 ml/min, ASL Avellino, Italy, March 2021–March 2023237 completed
- Outcome
- Association between albuminuria and cognitive impairment (MoCA score)
Methodological detailsconsecutive patients, 3-month follow-up
- Consecutive patients
- 3-month follow-up
Main finding
As reported in the abstract
- Significant inverse correlation between albuminuria and MoCA score (r)
- 0.8846; p < 0.0001
- MoCA score differed significantly by eGFR
- p < 0.0001
Observational data: associations, not effects.
Further findings
Multivariable regression with albuminuria as dependent variable
- Findings further supported by multivariable regression analysis
Original publication
Frail hypertensive older adults with prediabetes and chronic kidney disease: insights on organ damage and cognitive performance - preliminary results from the CARYATID study. Cardiovasc Diabetol. Published 10 April 2024. doi:10.
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