Coeliac disease and type 2 diabetes risk: a nationwide matched cohort and Mendelian randomisation study
Main finding · Incident T2DResult — go to the resultHazard ratio 1.00 95% CI 0.97–1.03Authors' conclusion
Coeliac disease was not associated with type 2 diabetes risk.
Study context
- Population
- Swedish ESPRESSO cohort, followed up from 1969 to 2021matched cohort
- Participants
- 46,150 vs 219,763
- Exposure
- Coeliac disease vs matched comparator individuals from the general population
- Coeliac diseasen = 46,150
- Comparatorn = 219,763reference
- Outcome
- Incident T2D
- Follow-up
- Median 15.7 years'
Main finding
As reported in the abstract
Hazard ratio
1.00
95% CI 0.97–1.03
Events by group
Coeliac diseasevs Comparator
HR 1.00 (95% CI 0.97–1.03)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| T2D risk: persistent villous atrophyvs mucosal healing (second biopsy, n=9053) | 1.02 (0.90–1.16) | |
| 0.512Hazard ratio (log scale) |
Mendelian randomisation: genetic liability to coeliac disease and T2D (DIAGRAM)
| OR (95% CI) | ||
|---|---|---|
| Genetic liability to coeliac diseaseDIAGRAM, 80,154 cases | 1.01 (0.99–1.03) | |
| 0.512Odds ratio (log scale) |
Mendelian randomisation: genetic liability to coeliac disease and T2D (FinnGen)
| OR (95% CI) | ||
|---|---|---|
| Genetic liability to coeliac diseaseFinnGen, 42,593 cases | 1.01 (0.99–1.04) | |
| 0.512Odds ratio (log scale) |
Original publication
Coeliac disease and type 2 diabetes risk: a nationwide matched cohort and Mendelian randomisation study. Diabetologia. Published 21 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →