Hemoglobin A1c Trajectories During Pregnancy and Adverse Outcomes in Women With Type 2 Diabetes: A Danish National Population-Based Cohort Study
Authors' conclusion
Women with poor glycemic control in early pregnancy have lower odds of having an infant with LGA birth weight, but higher odds of having an infant with SGA birth weight and CM.
Study context
- Population
- All singleton pregnancies in women with T2D giving birth to a liveborn infant, Denmark, 2004–2019
- Participants
- 1,129 pregnancies
- Exposure
- Hemoglobin A1c (HbA1c) trajectory groups by early-pregnancy glycemic control: poor vs good (moderate also identified)
- Outcome
- Adverse obstetric and perinatal outcomes by HbA1c trajectory group
Methodological detailsnational, population-based, latent class linear mixed-model analysis
- National
- Population-based
- Latent class linear mixed-model analysis
Main finding
As reported in the abstract
Adverse perinatal outcomes, poor vs good early glycemic control
Each group vs goodEstimate (95% CI)
Poor
aOR (LGA birth weight) 0.57(0.40–0.83)
Poor
aOR (SGA birth weight) 2.49(2.00–3.10)
Poor
aOR (congenital malformation) 4.60(3.39–6.26)
Observational data: associations, not effects.
Further findings
- All groups attained estimated HbA1c <6.5% (48 mmol/mol) during pregnancy, with no differences between groups in the 3rd trimester
Original publication
Hemoglobin A1c Trajectories During Pregnancy and Adverse Outcomes in Women With Type 2 Diabetes: A Danish National Population-Based Cohort Study. Diabetes Care. Published 21 May 2024. doi:10.
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