Liraglutide’s Effect on Weight Management in Subjects With Pre-diabetes: A Systematic Review & Meta-Analysis
Pooled result · Change in body weightResult — go to the resultMD −4.95 kg 95% CI −5.16 to −4.73Authors' conclusion
While our meta-analysis suggests that liraglutide can reduce body weight, BMI, waist circumference, and HbA1c levels in individuals with pre-diabetes, the findings should be interpreted cautiously due to limitations such as the small number of trials and their short duration, and variability in dosages. Further randomized controlled trials examining long-term outcomes are essential to validate these findings and address the high heterogeneity among the studies included in this analysis.
Study context
- Population
- Individuals with pre-diabetes (excluding T2D); English-language RCTs from MEDLINE, Embase, ClinicalTrials.gov5 studies
- Participants
- 1,604 vs 859
- Comparison
- Liraglutide vs control
- Liraglutiden = 1,604
- Controln = 859reference
- Outcome
- Change from baseline in absolute body weight (kg)
Methodological detailsfixed-effect model, random-effects sensitivity analysis
- Fixed-effect model
- Random-effects sensitivity analysis
Pooled result
Change in body weight
MD
−4.95 kg
95% CI −5.16 to −4.73
Liraglutidevs Control
MD −4.95 kg (95% CI −5.16 to −4.73)
As reported in the abstract
Further pooled results
| Outcome | MD (kg/m²) (95% CI) | |
|---|---|---|
| BMII2 = 97% | −2.06 (−2.22 to −1.89) | |
| −3−2−101Difference, kg/m² (linear scale) |
| Outcome | MD (cm) (95% CI) | |
|---|---|---|
| Waist circumferenceI2 = 82% | −4.61 (−4.79 to −4.43) | |
| −6−4−202Difference, cm (linear scale) |
| Outcome | MD (%) (95% CI) | |
|---|---|---|
| HbA1cI2 = 100% | −0.33 (−0.34 to −0.31) | |
| −0.4−0.200.2Difference, % (linear scale) |
| Outcome | MD (mmol/L) (95% CI) | |
|---|---|---|
| LDL-CI2 = 99% | −0.36 (−0.39 to −0.33) | |
| −0.4−0.200.2Difference, mmol/L (linear scale) |
Safety
- Adverse event rate higher with liraglutide vs control; dropout rates relatively lower with liraglutide
Original publication
Liraglutide’s Effect on Weight Management in Subjects With Pre-diabetes: A Systematic Review & Meta-Analysis. Endocr Pract. Published 21 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →