Clinicopathological Features of CCDC6-RET and NCOA4-RET Fusions in Thyroid Cancer: A Single-Center Retrospective Cohort Study in a Chinese Population
Authors' conclusion
RET fusions are specific to PTC or DHGTC cases among Chinese thyroid cancer cases. CCDC6-RET and NCOA4-RET fusions exhibited distinct clinicopathological features, with NCOA4-RET being more aggressive.
Study context
- Population
- Chinese thyroid cancer cases, single centre100 primary RET-fusion cases
- Participants
- 2,300 participants
- Exposure
- CCDC6-RET vs NCOA4-RET fusions
- CCDC6-RETn = 78reference
- NCOA4-RETn = 22
- Outcome
- Predominant RET fusions and their clinicopathological characteristics
Methodological detailssingle-centre, next-generation sequencing on formalin-fixed, paraffin-embedded tissue
- Single-centre
- Next-generation sequencing on formalin-fixed, paraffin-embedded tissue
Main finding
As reported in the abstract
- RET fusions among 2234 papillary thyroid cancer (PTC) or differentiated high-grade thyroid carcinoma (DHGTC) cases
- 113 (5.06%)
Observational data: associations, not effects.
Further findings
Histological subtype: classical PTC
Recurrence: NCOA4-RET vs CCDC6-RET · follow-up · not statistically significant
P = 0.559
| Outcome | P value |
|---|---|
| Recurrence: RET fusion vs BRAFV600E mutation · follow-up | P = 0.018 |
- Age ≥45 years · more prevalent with NCOA4-RET
- P = 0.021
- DHGTC cases · more prevalent with NCOA4-RET
- P < 0.05
- Lymph node metastases · higher with NCOA4-RET
- P = 0.032
- Hashimoto's thyroiditis · higher with CCDC6-RET
- P < 0.001
- Thyroglobulin antibody levels · elevated with CCDC6-RET
- P = 0.018
- Histological subtype: classical PTC — CCDC6-RET in infiltrative follicular PTC
- 17.9%, 14/78
- Histological subtype: classical PTC — NCOA4-RET in solid PTC
- 27.3%, 6/22
- Histological subtype: classical PTC — NCOA4-RET in DHGTC
- 27.3%, 6/22
- Recurrence: RET fusion vs BRAFV600E mutation: RET fusion 5.0%
- Recurrence: RET fusion vs BRAFV600E mutation: BRAFV600E 0.0%
Compound mutations
- RET fusions with compound mutations associated with older age (≥45 years) and bilateral thyroid involvement
Original publication
Clinicopathological Features of CCDC6-RET and NCOA4-RET Fusions in Thyroid Cancer: A Single-Center Retrospective Cohort Study in a Chinese Population. Thyroid. Published 30 August 2024. doi:10.
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