Preoperative Serum Lipids as Novel Predictors of Survival in 3575 Patients With Papillary Thyroid Cancer
Authors' conclusion
In the present study, we provide initial evidence that low levels of TAG and HDL were independently associated with the recurrence of PTC, indicating that preoperative serum concentrations of lipids are helpful in predicting the prognosis for patients with PTC in clinical practice.
Study context
- Population
- Patients with papillary thyroid cancer (PTC), 2012–2016, with follow-up at one institute; lipid cut-offs by ROC
- Participants
- 3,575 patients
- Exposure
- Low vs high preoperative serum lipid levels
- Outcome
- PTC recurrence (DFS)
- Follow-up
- Mean 56.7 months
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Recurrence
Hazard ratio (95% CI)
Low TAGvs High TAGmultivariable Cox
2.20(1.30–3.72)
Low HDLvs High HDL
1.60(1.00–2.57)
Observational data: associations, not effects.
Further findings
| Outcome | Low TAG | High TAG | P value |
|---|---|---|---|
| 5-year DFS by TAG · 5 yearsLow TAG vs High TAG | 94.4% | 97.2% | P < 0.001 |
Other lipids and recurrence
- Cholesterol not correlated with recurrence
- P = 0.13
- LDL-C not correlated with recurrence
- P = 0.07
- VLDL not correlated with recurrence
- P = 0.15
Nomogram c-index for disease-free survival (DFS) (training cohorts)
- 3-year DFS c-index
- 0.80 (95% CI 0.73-0.87)
- 4-year DFS c-index
- 0.82 (95% CI 0.73-0.90)
Original publication
Preoperative Serum Lipids as Novel Predictors of Survival in 3575 Patients With Papillary Thyroid Cancer. J Clin Endocrinol Metab. Published 30 August 2024. doi:10.
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