Defining the Functional Sensitivity for the Siemens Atellica Calcitonin Assay: Insight From a Single-Center Study
Authors' conclusion
Our findings indicate the potential suitability of a 5 pg/mL calcitonin cutoff on the Siemens Atellica platform for evaluating tumor persistence or recurrence in post-thyroidectomy patients in our institution. However, individual laboratories should establish their own clinical cutoff value when evaluating calcitonin levels for monitoring tumor recurrence post-thyroidectomy.
Study context
- Population
- Patients ≥3 months post-total thyroidectomy for MTC with calcitonin measured on Siemens Atellica, Sept 2022–Aug 2023; imaging within 6 months of calcitonin report56 samples
- Participants
- 40 patients
- Comparison
- Calcitonin cutoffs 1.89 pg/mL vs 5.00 pg/mL on Siemens Atellica assay
- Outcome
- Diagnostic accuracy of calcitonin cutoffs for persistent or recurrent MTC confirmed by imaging
Methodological detailssingle-centre
- Single-centre
Performance
As reported in the abstract
Persistent or recurrent MTC confirmed by imaging
| Strategy | Sensitivity | Specificity |
|---|---|---|
| 1.89 pg/mL cutoff | 43% | 67% |
| 5.00 pg/mL cutoff | 0% | 100% |
Sensitivity
1.89 pg/mL cutoff43%
5.00 pg/mL cutoff0%
Specificity
1.89 pg/mL cutoff67%
5.00 pg/mL cutoff100%
Further findings
Assay precision (CV)
- CV at 2.94 pg/mL
- 16.49%
- CV at 5.24 pg/mL
- 8.87%
Original publication
Defining the Functional Sensitivity for the Siemens Atellica Calcitonin Assay: Insight From a Single-Center Study. Endocr Pract. Published 26 August 2024. doi:10.
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