Two Decades of Thyroid Nodule Cytology in Children: Malignancy Risk Assessment at a Tertiary Care Center
Authors' conclusion
This study reveals that indeterminate thyroid nodules in pediatric patients exhibit a higher rate of malignancy compared to adults, yet align with rates previously reported in the pediatric population. These findings highlight the critical need for guidelines tailored specifically to the management of thyroid nodules and thyroid cancer in children.
Study context
- Population
- Patients under 19 years with thyroid nodules who underwent fine-needle aspiration (FNA) and thyroidectomy at a tertiary care center73 patients
- Participants
- 75 participants
- Exposure
- FNA cytology vs surgical histology
- Bethesda In = 2
- Bethesda IIn = 13
- Bethesda IIIn = 7
- Bethesda IVn = 14
- Bethesda Vn = 10
- Bethesda VIn = 29
- Outcome
- Risk of malignancy (ROM) per TBSRTC category and diagnostic accuracy (sensitivity, specificity, PPV, NPV) of FNA vs histology
Methodological detailssingle-centre, tertiary care center, histology as gold standard
- Single-centre
- Tertiary care center
- Histology as gold standard
Main finding
As reported in the abstract
ROM by TBSRTC category
- FNA sensitivity for malignancy
- 78.38%
- FNA specificity for malignancy
- 100%
- Sensitivity for detecting neoplasia in the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) IV
- 100%
Observational data: associations, not effects.
Further findings
Histology of nodules
- Benign
- 28 (37.3%)
- Malignant
- 47 (62.6%)
- No significant differences in gender or age between groups
Original publication
Two Decades of Thyroid Nodule Cytology in Children: Malignancy Risk Assessment at a Tertiary Care Center. Horm Res Paediatr. Published 26 August 2024. doi:10.
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