The American Thyroid Association risk classification of papillary thyroid cancer according to presurgery cytology
Main finding · ATA risk classificationResult — go to the resultOdds ratio 4.6 95% CI 1.523–14.007Authors' conclusion
Papillary thyroid cancers recorded among ITNs are likely less aggressive and are generally assessed as at lower risk according to ATA classification.
Study context
- Population
- Patients with histologically proven papillary thyroid cancer (PTC) stratified by preoperative fine-needle aspiration cytology
- Participants
- 51 vs 118
- Exposure
- TIR 4/5 cytology vs ITN cytology
- Indeterminate thyroid nodules (ITNs)n = 51reference
- TIR 4/5n = 118
- Outcome
- ATA risk classification
Main finding
As reported in the abstract
Odds ratio
4.6
95% CI 1.523–14.007
P = 0.007
TIR 4/5vs ITNs
OR 4.6 (95% CI 1.523–14.007); P = 0.007
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| US featuresTIR 4/5 vs ITNs · hypoechoic more frequent in TIR 4/5 | P = 0.037 |
| US featuresTIR 4/5 vs ITNs · irregular margins more frequent in TIR 4/5 | P = 0.041 |
| US featuresTIR 4/5 vs ITNs · microcalcifications more frequent in TIR 4/5 | P = 0.020 |
| US featuresTIR 4/5 vs ITNs · EU-TIRADS high-risk more frequent in TIR 4/5 | P = 0.021 |
| HistologyTIR 4/5 vs ITNs | P = 0.002 |
| HistologyTIR 4/5 vs ITNs · focal vascular invasion higher in TIR 4/5 | P < 0.001 |
| HistologyTIR 4/5 vs ITNs · neck lymph node metastasis higher in TIR 4/5 | P = 0.028 |
| RAI treatmentMore patients receiving RAI in TIR 4/5 | P = 0.002 |
- Histology: follicular PTC subtype more prevalent among ITNs; classical PTC more frequent in TIR 4/5
US features
- Male/female ratio, age and presurgery TSH similar between groups
Original publication
The American Thyroid Association risk classification of papillary thyroid cancer according to presurgery cytology. Eur J Endocrinol. Published 31 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →