Beyond Malignancy Risk Stratification: Fine-needle-aspiration-cytology (FNAC) Report Anticipates Thyroid Cancer Staging. Insights From Recent Studies
Authors' conclusion
These results were consistent in both studies and strongly point toward a more indolent clinical phenotype of DTC with a preoperative diagnosis of ITN as opposed to suspicious for malignancy or malignant.
Study context
- Population
- Histologically proven thyroid cancer with presurgical FNAC; 2 recent studies from Europe and the United States (Italian and Bethesda classification systems)2 studies
- Comparison
- Differentiated thyroid cancer (DTC) with preoperative indeterminate thyroid nodule (ITN) cytology vs suspicious for malignancy or malignant cytology
- Outcome
- Clinical presentation of TC by presurgical FNAC result
Methodological detailsexpert commentary on two recent studies
- Expert commentary on two recent studies
Main finding
As reported in the abstract
- Thyroid cancer (TC) with initial ITN diagnosis (especially PTC) had a less aggressive clinical presentation, with lower rates of lymph node metastasis, more aggressive variants and BRAFV600E mutations vs DTC with initial diagnosis of suspicious for malignancy or malignant
- Results were consistent in both studies, pointing to a more indolent phenotype of DTC with preoperative ITN
Original publication
Beyond Malignancy Risk Stratification: FNAC Report Anticipates Thyroid Cancer Staging. Insights From Recent Studies. J Clin Endocrinol Metab. Published 1 October 2024. doi:10.
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