Clinicopathological and Molecular Profile of Sellar Neurocytoma
Authors' conclusion
Hyponatremia is the dominant clinical features of SN. Preoperative imaging suggests that growth toward the dorsal region is the imaging feature of SN. SSTR2 expression and LMCD1-AS1:GRM7-AS1 fusion gene event expected to become a new molecular marker for SN. Somatostatin receptor ligand therapy may be a potential therapy for SN.
Study context
- Population
- Patients with sellar neurocytoma (SN)EM in 5 cases
- Participants
- 11 patients
- Outcome
- Clinical, imaging and molecular features of SN
Methodological detailsElectron microscopy in 5 cases; RNA sequencing, quantitative PCR and immunohistochemistry of tumor tissue
- Electron microscopy in 5 cases; RNA sequencing, quantitative PCR and immunohistochemistry of tumor tissue
Main finding
As reported in the abstract
Hyponatremia
73%, 8/11
Increased expression of hypothalamus-secreted hormones
10
Differentially expressed genes verified by quantitative PCR
15
Observational data: associations, not effects.
Original publication
Clinicopathological and Molecular Profile of Sellar Neurocytoma. J Clin Endocrinol Metab. Published 16 April 2024. doi:10.
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