Clinical Significance of Successful Ablation in Follicular Thyroid Carcinoma
Authors' conclusion
Patients with FTC with successful ablation achieved excellent 10-year CSS and DMFS rates of 100%. Therefore, careful follow-up may be unnecessary for these patients even if they have negative prognostic factors.
Study context
- Population
- Patients with follicular thyroid carcinoma (FTC)
- Participants
- 428 patients
- Exposure
- Postoperative ablation vs observation; successful vs unsuccessful ablation
- Ablationn = 216
- Observationn = 212reference
- Outcome
- Predictive factors for successful ablation and association of successful ablation with clinical outcomes of FTC
Main finding
As reported in the abstract
Independent predictor of successful ablation (multivariate analysis)
Successful ablation among 116 patients with postoperative ablation following diagnostic I-131 scintigraphy
65
56%
Observational data: associations, not effects.
Further findings
10-year CSS, ablation group, with vs without successful ablation
P = 0.246
10-year DMFS, with vs without successful ablation
P < 0.001
- 10-year cause-specific survival (CSS), ablation group, with vs without successful ablation — Deaths with successful ablation during follow-up
- 0
- 10-year distant-metastasis-free survival (DMFS), with vs without successful ablation — Distant metastatic recurrence with successful ablation during follow-up
- 0
- 10-year CSS, ablation group, with vs without successful ablation: n = 65 with and n = 151 without successful ablation
Baseline characteristics, ablation vs observation
- Ablation group significantly older (P < .001)
- Higher prevalence of widely invasive-FTC histology with ablation (P < .001)
- Higher rate of antithyroglobulin antibody positivity with ablation (P = .007)
Original publication
Clinical Significance of Successful Ablation in Follicular Thyroid Carcinoma. J Clin Endocrinol Metab. Published 4 June 2025. doi:10.
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