Clinical characteristics and long‐term outcomes for parapharyngeal metastases of well‐differentiated thyroid cancer during 131I therapy and follow‐up
Authors' conclusion
The therapeutic effect for PPM was closely associated with 131 I avidity, age at initial PPM diagnosis, and maximal size of PPM at the end of follow-up. Age of ≥55 years at initial diagnosis of PPM and the presence of concomitant distant metastasis were independently associated with poor survival.
Study context
- Population
- Patients with parapharyngeal metastases (PPM) from well-differentiated thyroid cancer, among 14,984 consecutive DTC patients treated with 131 I after total or near-total thyroidectomy, 2004–2021; 32 men, 43 women
- Participants
- 75 patients
- Outcome
- Clinicopathological features and long-term outcomes (therapeutic response, disease-specific survival) of PPM
- Follow-up
- End
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
- Progressive disease
- 22 (29.33%)
- Died
- 16 of 75
- Excellent response
- 6 (8.00%)
- Indeterminate response
- 6 (8.00%)
- Biochemical incomplete response
- 10 (13.33%)
- Structural incomplete response
- 37 (49.33%)
- 5-year disease-specific survival (DSS)
- 98.49%
- 10-year DSS
- 62.10%
Observational data: associations, not effects.
Further findings
Factors for progressive disease of PPM lesions (multivariate)
- Age at initial PPM diagnosis
- P = 0.03
- Maximal size of PPM
- P = 0.02
- 131 I avidity
- P < 0.01
Factors independently associated with poor prognosis
- Age ≥55 years at initial PPM diagnosis
- P = 0.03
- Concomitant distant metastasis
- P = 0.04
Baseline characteristics
- Age at initial PPM diagnosis
- 40.2 ± 14.1 years
- Combined distant metastases
- 43 (57.33%)
- 131 I avidity
- 57 (76.00%)
- Non-131 I avidity
- 18
Original publication
Clinical characteristics and long‐term outcomes for parapharyngeal metastases of well‐differentiated thyroid cancer during 131I therapy and follow‐up. Clin Endocrinol (Oxf). Published 27 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →