A Novel Protocol for Pre-Treatment Diagnostic 131 I Scan Within 24 Hours Post-Second rhTSH Administration to Guide Radioiodine Therapy in Differentiated Thyroid Cancer
Authors' conclusion
The rhTSH-aided Dx-WBS and sTg, performed within 24 hours post-second rhTSH injection, are reliable and efficient in enabling pre-RAIT disease evaluation and subsequent RAIT within the same two-injection cycle, providing a cost-effective strategy.
Study context
- Population
- Patients with differentiated thyroid carcinoma (DTC) after total thyroidectomy receiving rhTSH (0.9 mg daily on 2 consecutive days), low-dose diagnostic 131I about 6 h after second injection, then radioiodine therapy (RAIT) after the 24-h Dx-WBS
- Participants
- 110 patients
- Comparison
- Dx-WBS at 12, 18 and 24 h post-second rhTSH injection vs post-treatment Rx-WBS (reference standard)
- Outcome
- Concordance of Dx-WBS with Rx-WBS
Methodological detailssingle-centre
- Single-centre
Performance
As reported in the abstract
Concordance with Rx-WBS
P < 0.05
Further findings
| Outcome | 24-hour sTg | 6-hour sTg | P value |
|---|---|---|---|
| Concordance of sTg category with 72-hour sTg (TgAb-negative patients; <1, 1-10, ≥10 ng/mL) | 89.3% (CI 80.1–95.3%) | 72.0% (CI 60.4–81.8%) | P < 0.05 |
Original publication
A Novel Protocol for Pre-Treatment Diagnostic 131 I Scan Within 24 Hours Post-Second rhTSH Administration to Guide Radioiodine Therapy in Differentiated Thyroid Cancer. Thyroid. Published 24 August 2026. doi:10.
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