Circulating lipid subfractions and the risk of longitudinal adiposity progression: findings from the China Kadoorie Biobank
Authors' conclusion
Cholesterol-enriched lipoproteins, particularly in medium-to-small subclasses, may contribute to long-term obesity progression risk, while elevated TG subfractions primarily reflect current obesity status.
Study context
- Population
- China Kadoorie Biobank participants with baseline NMR data and anthropometric measurements at baseline and second resurvey
- Participants
- 1,502 participants
- Exposure
- Per SD higher circulating lipid subfraction trait
- Outcome
- Excessive adiposity increase: BMI increase of ≥5% from baseline
- Follow-up
- Median 8 years
Methodological detailsChina Kadoorie Biobank, modified Poisson regression
- China Kadoorie Biobank
- Modified Poisson regression
Main finding
As reported in the abstract
Participants with ≥5% increase in body mass index (BMI)
33.3%
High baseline cholesterol percentages in most LDL and high-density lipoprotein (HDL) subclasses: elevated risk of excess adiposity increase (RRs per SD)
1.09-1.18
Triglyceride (TG) enrichment in most lipoprotein particles, except larger VLDL particles: inverse association with adiposity progression (RRs per SD)
0.90-0.80
Observational data: associations, not effects.
Further findings
- Most TG-enriched subfractions were associated with baseline obesity status but inversely with longitudinal adiposity progression
- Cholesterol enrichment in HDL and LDL subclasses was associated with long-term adiposity increases, yet inversely with baseline adiposity
Original publication
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