Relative Skeletal Muscle Mass Is Associated With Hepatic Steatosis in Adolescents With Overweight and Obesity
Authors' conclusion
Low ALM index had a significant association with hepatic steatosis in adolescents with OO, bringing attention to the interplay between muscle mass and hepatic steatosis in this population. This finding has potential implications for optimal management of metabolic dysfunction-associated steatotic liver disease (MASLD), while the relationship between muscle mass and insulin sensitivity/glycemia requires further attention.
Study context
- Population
- Adolescents with BMI from OO to healthy weight (HW); OO mean age 15.2 ± 2.4 years, 88.2% female; HW 13.7 ± 2.6 years, 59.2% female
- Participants
- 304 adolescents
- Comparison
- Adolescents with overweight/obesity vs healthy weight
- OOn = 228
- HWn = 76reference
Methodological detailscross-sectional, multivariable linear regression
- Cross-sectional
- Multivariable linear regression
Primary result
As reported in the abstract
ALM index (ALM/weight × 100)
P < 0.01
Further findings
Association of appendicular lean mass (ALM) index with square-root-transformed HFF
- β
- −0.09
- SE
- 0.03
- T-value
- −2.92
- p
- P < 0.01
Association of ALM index with fasting C-peptide and other insulin sensitivity/glycemia markers
- ALM index negatively associated with fasting C-peptide
- P < 0.01
- No association with other markers of insulin sensitivity/glycemia
Original publication
Relative Skeletal Muscle Mass Is Associated With Hepatic Steatosis in Adolescents With Overweight and Obesity. Pediatr Obes. Published 21 April 2026. doi:10.
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