Association of dietary patterns, circulating lipid profile, and risk of obesity
Authors' conclusion
The newly affluent southern pattern points to an altered lipid profile, which showed higher general and central obesity risks. These findings partly suggest the biological mechanism for the obesogenic effects of this DP.
Study context
- Population
- Participants of the China Kadoorie Biobank, average age 47.0; 12-item food frequency questionnaire; 129 lipid-related plasma metabolites
- Participants
- 4,778 participants
- Exposure
- Dietary patterns vs lipid profile and obesity risk
- Outcome
- Lipid profile mediation of dietary patterns (DP) effects on obesity
Methodological detailsfactor analysis, targeted nuclear magnetic resonance (NMR) spectroscopy, mediation analysis
- Factor analysis
- Targeted NMR spectroscopy
- Mediation analysis
Main finding
As reported in the abstract
Newly affluent southern pattern positively associated with metabolites, which were positively associated with obesity risks
45 metabolites
Share of effect of newly affluent southern pattern on general obesity explained by global lipid profile
30.9%
Share of effect on waist circumference-defined central obesity explained by global lipid profile
34.7%
Share of effect on WHR-defined central obesity explained by global lipid profile
53.1%
Observational data: associations, not effects.
Original publication
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