Cardiovascular risk of metabolically healthy obesity in two european populations: Prevention potential from a metabolomic study
Authors' conclusion
Individuals with MHO may not present higher short-term cardiovascular risk but tend to have a metabolomic pattern associated with higher cardiovascular risk, emphasizing a need for early intervention.
Study context
- Population
- Europeans from two population-based studies (FLEMENGHO, Hortega); mean age 51 years, 49.6% women, 18.6% with obesity2,218 with metabolomic profiling
- Participants
- 2,339 participants
- Exposure
- BMI category by metabolic health status vs metabolically healthy normal weight
- Metabolically healthy obesity (MHO)n = 117
- Outcome
- Fatal and nonfatal composite CV events
- Follow-up
- Median 9.2-year (3.7-13.0)
Methodological detailstwo population-based cohorts (FLEMENGHO and Hortega), metabolomic profiling
- Two population-based cohorts (FLEMENGHO and Hortega)
- Metabolomic profiling
Main finding
As reported in the abstract
Fatal and nonfatal composite CV events (245 events) · median 9.2-year follow-up
Each group vs metabolically healthy normal weightEstimate (95% CI)
Metabolically unhealthy normal weight
aHR 3.30(1.73–6.28)
Metabolically unhealthy overweight
aHR 2.50(1.34–4.66)
Metabolically unhealthy obesity
aHR 3.42(1.81–6.44)
MHO
HR 1.11(0.36–3.45)
Observational data: associations, not effects.
Further findings
| Outcome | MHO | Metabolically healthy normal weight | Metabolically unhealthy obesity | P value |
|---|---|---|---|---|
| Metabolomic factor scoreMHO vs Metabolically healthy normal weight · higher with MHO | 0.175 | −0.057 | −0.080 | P = 0.019 |
| Metabolomic factor scoreMHO vs Metabolically unhealthy obesity · comparable | P = 0.91 |
Metabolomic factor (mainly glucose regulation) and CV events
- HR for CV events per metabolomic factor
- 1.22 (95% CI: 1.10-1.36)
Original publication
Cardiovascular risk of metabolically healthy obesity in two european populations: Prevention potential from a metabolomic study. Cardiovasc Diabetol. Published 7 April 2023. doi:10.
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