Circadian Alignment, Cardiometabolic Disease, and Sex-Specific Differences in Adults With Overweight/Obesity
Authors' conclusion
Circadian disruption may not only promote a trajectory of weight gain but could also contribute to negative health consequences in a sex-dependent manner in those already with overweight/obesity. These data may have implications for clinical utility in sex-specific sleep and circadian interventions for adults with overweight/obesity.
Study context
- Population
- Adults with overweight/obesity (BMI ≥25.1 kg/m²); 15 female15 female
- Participants
- 30 adults
- Exposure
- Narrow vs wide phase angle, by sex
- Outcome
- Cardiometabolic markers, narrow vs wide phase angle, by sex
Methodological detailsin-laboratory assessment, median phase angle split, sex-stratified, dim-light melatonin onset (DLMO), DXA body composition and fasted blood sample at an evening in-laboratory assessment
- In-laboratory assessment
- Median phase angle split
- Sex-stratified
- DLMO, DXA body composition and fasted blood sample at an evening in-laboratory assessment
Main finding
As reported in the abstract
Males: narrower phase angle vs android/gynoid body fat
r = −0.53
P = .04
Females: narrower phase angle vs body fat
r = −0.62
P = .01
Females: narrower phase angle vs heart rate
r = −0.73
P < .01
Observational data: associations, not effects.
Original publication
Circadian Alignment, Cardiometabolic Disease, and Sex-Specific Differences in Adults With Overweight/Obesity. J Clin Endocrinol Metab. Published 20 August 2024. doi:10.
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