Characterizing the effect of bariatric surgery on circulating S100A9
Authors' conclusion
We found that S100A9 concentrations differ substantially between blood components, are elevated in obesity, and normalize post-BS. Reductions in circulating S100A9 may contribute to reduced inflammation and be largely driven by resolution of obesity-associated neutrophilia. Our data suggest minimal platelet contribution to circulating (or systemic) S100A9, but a local level inflammatory impact cannot be excluded.
Study context
- Population
- Subjects with obesity undergoing bariatric surgery and lean volunteers
- Participants
- 23 vs 8
- Comparison
- Subjects with obesity pre- vs post-BS, and vs lean volunteers
- Obesityn = 23
- Leann = 8reference
- Outcome
- S100A9 levels in serum, plasma and platelet supernatants
- Follow-up
- 1-year post-BS
Methodological detailspre- and post-BS comparison, lean controls
- Pre- and post-BS comparison
- Lean controls
Main finding
As reported in the abstract
S100A9 levels
- Serum and plasma S100A9 elevated in obesity vs lean
- Serum and plasma S100A9 decreased to lean levels at 1-year post-BS, despite subjects remaining overweight
- Circulating neutrophil counts decreased post-BS; post-BS differences in serum S100A9 eliminated when calculated per-neutrophil
- Platelet supernatant S100A9 lower than serum and plasma and did not change post-BS
- Platelet supernatant S100A9 correlated with plasma, but not serum, levels
Original publication
Characterizing the effect of bariatric surgery on circulating S100A9. Int J Obes (Lond). Published 28 July 2025. doi:10.
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