Changes in Collagen Type I C-Telopeptide and Procollagen Type I N-Terminal Propeptide During the Menopause Transition
Authors' conclusion
CTX and PINP are stable in premenopause, increase during the MT, and decrease in postmenopause. During the MT and postmenopause, bone turnover change rates vary by race/ethnicity.
Study context
- Population
- Women from the Study of Women's Health Across the Nation who transitioned from pre- to postmenopause
- Participants
- 541 women
- Exposure
- Black vs Chinese vs Japanese vs White
- Blackn = 126
- Chinesen = 90
- Japanesen = 87
- Whiten = 238reference
- Outcome
- CTX and P1NP trajectories relative to years from final menstrual period (FMP)
Methodological detailscommunity-based, 18-year longitudinal analysis, multivariable mixed effects piecewise linear regression
- Community-based
- 18-year longitudinal analysis
- Multivariable mixed effects piecewise linear regression
Main finding
As reported in the abstract
- CTX increase per year during menopause transition (MT) (3 years before to 3 years after final menstrual period (FMP))
- 10.3% (P < .0001)
- P1NP increase per year during MT
- 7.5% (P < .0001)
- MT-related total gain, CTX
- 61.9%
- MT-related total gain, P1NP
- 45.2%
- CTX decrease per year from 3 years post-FMP (postmenopause)
- 3.1% (P < .0001)
- P1NP decrease per year in postmenopause
- 2.9% (P < .0001)
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Race/ethnicity differences in CTX and P1NP change during MTChinese vs White · larger gains in CTX with Chinese | P = 0.01 |
| Race/ethnicity differences in CTX and P1NP change during MTJapanese vs White · greater increases in CTX with Japanese | P < 0.0001 |
| Race/ethnicity differences in CTX and P1NP change during MTJapanese vs White · greater increases in P1NP with Japanese | P = 0.02 |
| Race/ethnicity differences in CTX and P1NP change in postmenopauseJapanese vs White · CTX rose more with Japanese | P = 0.01 |
| Race/ethnicity differences in CTX and P1NP change in postmenopauseJapanese vs White · P1NP rose more with Japanese | P = 0.01 |
Original publication
Changes in Collagen Type I C-Telopeptide and Procollagen Type I N-Terminal Propeptide During the Menopause Transition. J Clin Endocrinol Metab. Published 13 December 2023. doi:10.
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