ChAdOx1 SARS‐CoV‐2 vaccination: A putative precipitant of adrenal crises
Authors' conclusion
In individuals with adrenal insufficiency, adverse reactions to the initial dose of the ChAdOx1 SARS-CoV-2 vaccination can precipitate adrenal crises. We recommend that patients with AI should immediately increase their maintenance glucocorticoid dosage 2-3 fold on experiencing any symptoms in the initial 24 h following vaccination.
Study context
- Population
- Patients with adrenal insufficiency (AI) who received the first ChAdOx1 SARS-CoV-2 vaccination
- Participants
- 5 patients
- Outcome
- Actual or incipient adrenal crises requiring parenteral hydrocortisone after first ChAdOx1 SARS-CoV-2 vaccination
- Follow-up
- Within 24 h
Main finding
As reported in the abstract
- Cases where more severe adverse reactions to ChAdOx1 vaccine led to actual or incipient adrenal crises requiring parenteral hydrocortisone
- 5
Observational data: associations, not effects.
Original publication
ChAdOx1 SARS‐CoV‐2 vaccination: A putative precipitant of adrenal crises. Clin Endocrinol (Oxf). Published 6 August 2021. doi:10.
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