Clinical Course of COVID-19 in Children With Adrenal Insufficiency: Results From National Data
Authors' conclusion
Our findings do not indicate that AI is associated with increased susceptibility to SARS-CoV-2 infection or higher risk for severe COVID-19 in children.
Study context
- Population
- Children with adrenal insufficiency (AI) (cohort of 1143); those infected with SARS-CoV-2 evaluated for COVID-19 severity and outcomes, Italy148 infected with AI
- Participants
- 1,143 children
- Exposure
- Children with AI vs controls with normal adrenal function
- AIn = 148
- Controlsn = 74reference
- Outcome
- Susceptibility to SARS-CoV-2 infection and severity of COVID-19
Methodological detailsmulticenter
- Multicenter
Main finding
As reported in the abstract
- Prevalence of COVID-19 in AI cohort, not increased vs pediatric Italian population in the same period
- 12.9%
- Asymptomatic, AI vs controls
- 14.9% vs 10.8%
- Paucisymptomatic, AI vs controls
- 33.8% vs 37.8%
- Mild, AI vs controls
- 45.3% vs 45.9%
- Severe, AI vs controls
- 3.4% vs 2.7%
- Critical, AI vs controls
- 2.7% vs 2.7%
Observational data: associations, not effects.
Further findings
Pneumonia among those with severe COVID
P not statistically significant
Multisystem inflammatory syndrome among those with severe COVID (primary AI) · AI cases were patients with PAI
P not statistically significant
Hospitalization rate
Safety
Adrenal crisis, recovery and deaths
- Adrenal crisis during severe COVID-19
- 5 patients (3.4%)
- All subjects completely recovered; COVID-related deaths
- 0
Original publication
Clinical Course of COVID-19 in Children With Adrenal Insufficiency: Results From National Data. J Clin Endocrinol Metab. Published 7 February 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →