Gestational diabetes & diabetes in pregnancy
Continuous Glucose Monitoring (CGM) Metrics and the Risk of Pregnancy Complications in Type 1 Diabetes: A Secondary Exploratory Analysis of the CRISTAL Trial
Authors' conclusion
Specific combinations of CGM metrics, including overnight TIRp/TARp, may be informative for predicting pregnancy outcomes. GMI and HbA1c should not be considered interchangeable for glycemic control during pregnancy.
Study context
- Population
- Pregnant women with T1D using CGM
- Participants
- 95 women
Methodological detailssecondary exploratory analysis
- Secondary exploratory analysis
Primary result
As reported in the abstract
Associations of CGM metrics with pregnancy outcomes (OR adjusted for baseline HbA1c)
- Per 5% increase in overall TIRp: gestational hypertension, OR
- 0.63 (0.41-0.97) (95% CI)
- Per 5% increase in overall TIRp: birthweight >4.5 kg, OR
- 0.56 (0.32-0.96) (95% CI)
- Per 5% increase in overall TIRp: neonatal hypoglycemia requiring hospital care, OR
- 0.09 (0.01-0.57) (95% CI)
- Per 5% increase in overnight TIRp: gestational hypertension, OR
- 0.71 (0.52-0.98) (95% CI)
- Per 5% increase in overnight TIRp: neonatal hypoglycemia requiring hospital care, OR
- 0.15 (0.03-0.79) (95% CI)
- Per 5% increase in overall TARp: birthweight >4.5 kg, OR
- 1.76 (1.05-2.96) (95% CI)
- Per 5% increase in overall TARp: respiratory distress, OR
- 1.55 (1.02-2.37) (95% CI)
- Per 5% increase in overall TARp: neonatal hypoglycemia requiring hospital care, OR
- 5.10 (1.14-22.78) (95% CI)
- Per 5% increase in overnight TARp: hospital care for neonatal hypoglycemia, OR
- 2.55 (1.15-5.66) (95% CI)
- Per 0.28 mmol/L increase in mean glucose: respiratory distress, OR
- 1.54 (1.07-2.23) (95% CI)
- Per 0.5% increase in glucose management indicator (GMI): respiratory distress, OR
- 6.15 (1.33-28.40) (95% CI)
- Per 0.28 mmol/L increase in glycemic variability (SD): gestational hypertension, OR
- 1.69 (1.02-2.80) (95% CI)
- Per 0.28 mmol/L increase in glycemic variability (SD): birthweight >4.5 kg, OR
- 2.31 (1.20-4.43) (95% CI)
Further findings
Discriminative performance of combined CGM metrics
- Several combinations of CGM metrics (TIRp[-night], TARp[-night], SD, mean glucose) improved discriminative performance for pregnancy outcomes
GMI validity vs HbA1c
- GMI and HbA1c values were discordant
Original publication
CGM Metrics and the Risk of Pregnancy Complications in Type 1 Diabetes: A Secondary Exploratory Analysis of the CRISTAL Trial. Diabetes Technol Ther. Published 12 August 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →