Celiac Disease in Children With Type 1 Diabetes: The Usefulness of Screening— 25 years of Experience in a Single Center
Authors' conclusion
We conclude that even highly elevated CD-specific antibodies can disappear in children with T1D and that screening for CD-specific antibodies is therefore only useful in symptomatic children with T1D.
Study context
- Population
- Children with T1D (diabetes onset since 1998) screened for celiac disease (CD)-specific antibodies in one outpatient clinic over 25 years; endoscopy not routinely recommended in antibody-positive patients without CD-specific symptoms
- Participants
- 304 children
- Outcome
- Development of CD-specific antibodies and CD diagnosis
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- Patients with CD-specific antibodies
- 122
- Antibodies disappeared after a short time or only slightly elevated
- 98
- CD diagnosis confirmed (all with CD-specific symptoms: failure to thrive, anemia, hypoglycemia or GI problems)
- 12
- Severely elevated EAb and/or TgAb disappeared on gluten-containing diet
- 6
- Mean time to antibody disappearance (range 4.9-13.5 years)
- 7.1 years
- Antibodies persisting without CD-specific symptoms at end of observation
- 6
- Duration of antibody-positivity in persisting group (range 1.8-11.6 years)
- 4 years
Observational data: associations, not effects.
Original publication
Celiac Disease in Children With Type 1 Diabetes: The Usefulness of Screening— 25 years of Experience in a Single Center. Pediatr Diabetes. Published 1 August 2025. doi:10.
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