Causal Effects of Metabolic Syndrome on Gastric Disorders: Univariable and Multivariable Mendelian Randomization
Authors' conclusion
The findings suggest that specific MetS components, such as TGs and HDL-C, may affect the risk of benign gastric tumors, while hypertension might reduce the risk of gastric cancer. This study highlights the need for further research to understand the underlying mechanisms and potential indirect effects between MetS components and gastric disorders.
Study context
- Population
- Chronic gastritis, benign gastric tumors and gastric cancer as outcomes of metabolic syndrome (MetS) components
- Comparison
- Genetically predicted MetS components and risk of gastric disorders
- Outcome
- Risks of chronic gastritis, benign gastric tumors and gastric cancer
Methodological detailsunivariable 2-sample mendelian randomization (MR), multivariable MR, random effects inverse-variance weighted primary method
- Univariable 2-sample MR
- Multivariable MR
- Random effects inverse-variance weighted primary method
Main finding
As reported in the abstract
- Elevated triglycerides (TGs) and benign gastric tumors, univariable TSMR: OR
- 1.223 (1.011-1.480); P = .0386 (95% CI)
- High-density lipoprotein cholesterol (HDL-C) and benign gastric tumors, univariable TSMR (reduced HDL-C with increased risk): OR
- 0.833 (0.701-0.989); P = .037 (95% CI)
- TGs and benign gastric tumors, multivariable mendelian randomization (MVMR) (not confirmed): OR
- 1.187 (0.891-1.581); P = .2408 (95% CI)
- HDL-C and benign gastric tumors, MVMR (not confirmed): OR
- 0.989 (0.758-1.289); P = .932 (95% CI)
- Hypertension and gastric cancer, TSMR: OR
- 0.585 (0.411-0.831); P = .003 (95% CI)
- Hypertension and gastric cancer, MVMR: OR
- 0.558 (0.334-0.930); P = .025 (95% CI)
Original publication
Causal Effects of Metabolic Syndrome on Gastric Disorders: Univariable and Multivariable Mendelian Randomization. J Clin Endocrinol Metab. Published 6 December 2024. doi:10.
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