Causal associations of remnant cholesterol with cardiometabolic diseases and risk factors: a mendelian randomization analysis
Authors' conclusion
This MR study demonstrates that genetically driven RC increases the risk of several CMD and cardiometabolic risk factors, suggesting that targeted RC-lowering therapies may be effective for the primary prevention of CMD.
Study context
- Population
- Summary-level statistics from individuals of predominantly European ancestry, mainly UK Biobank and FinnGen biobank
- Comparison
- Genetically predicted remnant cholesterol (RC) and cardiometabolic diseases (CMD) and cardiometabolic risk factors
- Outcome
- Causal associations of RC with cardiometabolic diseases (CMD)
Methodological detailsunivariable and multivariable Mendelian randomization (MR), bidirectional MR, inverse-variance weighted method (main)
- Univariable and multivariable MR
- Bidirectional MR
- Inverse-variance weighted method (main)
Main finding
As reported in the abstract
CMD (univariable MR)
- Genetically predicted RC causally associated with higher risk of ischemic heart disease, MI, AF and flutter, peripheral artery disease and non-rheumatic valve diseases
- all P < 0.05
- Multivariable MR: harmful effect of RC on risk of ischemic heart disease
- P < 0.05
Further findings
Cardiometabolic risk factors (bidirectional MR)
- RC bidirectionally causally linked to total cholesterol, TG, LDL-C and hypercholesterolemia
- all P < 0.05
- No genetic association between RC and metabolic disorders or the other cardiometabolic risk factors
Original publication
Causal associations of remnant cholesterol with cardiometabolic diseases and risk factors: a mendelian randomization analysis. Cardiovasc Diabetol. Published 10 August 2023. doi:10.
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