Hepatic steatosis with significant fibrosis is associated with an increased 10-year estimated risk of cardiovascular disease in adults with type 1 diabetes mellitus
Main finding · High 10-year estimated CVD risk (Steno type 1 risk engine)Result — go to the resultAdjusted odds ratio 11.4 95% CI 3.54–36.9Authors' conclusion
The 10-year estimated CVD risk is remarkably greater in T1DM adults with hepatic steatosis and significant fibrosis than in their counterparts with hepatic steatosis alone or without steatosis.
Study context
- Population
- Adults with established T1D without pre-existing cardiovascular disease (CVD)
- Participants
- 1,254 adults
- Exposure
- Hepatic steatosis with significant fibrosis vs steatosis alone vs no steatosis
- Steatosis + significant fibrosisn = 91
- Steatosis alonen = 509
- Without steatosisn = 654reference
- Outcome
- High 10-year estimated risk of a first fatal or nonfatal CVD event (Steno type 1 risk engine)
- Follow-up
- 10-year estimated
Methodological detailsmulticenter
- Multicenter
Main finding
As reported in the abstract
High 10-year estimated CVD risk (Steno type 1 risk engine)
Adjusted odds ratio
11.4
95% CI 3.54–36.9
By group
Steatosis + significant fibrosisvs Without steatosis
aOR 11.4 (95% CI 3.54–36.9)
- Difference across the three groups
- P < 0.001
Observational data: associations, not effects.
Further findings
10-year estimated CVD risk (atherosclerotic CVD (ASCVD) risk calculator)
- Almost identical results using the ASCVD risk calculator
Original publication
Hepatic steatosis with significant fibrosis is associated with an increased 10-year estimated risk of cardiovascular disease in adults with type 1 diabetes mellitus. Cardiovasc Diabetol. Published 10 August 2023. doi:10.
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